Phenobarbitone should be given for about
2 - 3 weeks to allow for serum levels to stabilise before
checking therapeutic concentrations.
Monitoring of therapeutic levels of phenobarbitone should
be assessed at 8 - 12 hours post treatment. Peak levels
occur about 5 hours post treatment.
Theraupetic levels for phenobarbitone are 15 - 40 mg/mL
Potassium Bromide
Serum levels of potassium
bromide may take at least 125 days to stabilise due to
the long half life of the drug.
Theraupetic levels for potassium bromide are 0.5 - 1.9
mg/mL. Young healthy dogs may tolerate levels up to 2.5
mg/mL and most dogs will tolerate levels up to 1.5 mg/mL.
Digoxin
Digoxin should be given for about
3 - 5 days to allow for serum levels to stabilise before checking
therapeutic concentrations.
Monitoring of therapeutic levels of digoxin should be assessed
at 8 hours post treatment. Digoxin concentrations of 0.8 - 2.0
ng/mL are required post treatment.
